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Effect of Septilin--a herbal preparation on pharmacokinetics of carbamazepine in rabbits

Garg, S.K.; Islam, A.S.; Kumar, N.

Indian Journal of Physiology and Pharmacology 42(4): 527-532

1998

ISSN/ISBN: 0019-5499
PMID: 10874355
Document Number: 495585
The study was carried out in rabbits, to see the effects of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1/2a. t 1/2e. AUCo-alpha of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine were also reduced significantly in comparison to those of control rabbits after 7 days co-administration of Septilin. We conclude that Septilin decrease/hinder the absorption process of carbamazepine through an unknown mechanism.

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