Effects of short-term lamotrigine treatment on pharmacokinetics of carbamazepine
Malminiemi, K.; Keränen, T.; Kerttula, T.; Moilanen, E.; Ylitalo, P.
International Journal of Clinical Pharmacology and Therapeutics 38(11): 540-545
2000
ISSN/ISBN: 0946-1965 PMID: 11097146 Document Number: 525508
Aim and method: The effects of short-term treatment with lamotrigine (LTG) (100 mg twice daily for one week) on single dose pharmacokinetics of carbamazepine (CBZ, 200 mg) were investigated in a randomized, double-blinded, placebo-controlled cross-over study with 10 healthy volunteers. Results: Pharmacokinetic parameters for CBZ or for CBZ-10, 11-epoxide, the main metabolite of CBZ, were not significantly affected by LTG pretreatment. The mean (+- SEM) elimination half-life of CBZ was 33.0 +- 1.8 h after pretreatment with placebo and 30.1 +- 2.0 h after a one-week-pretreatment with LTG (NS). The area under the serum concentration curve to infinity (AUC) of CBZ was 638 +- 45 mumol/l after placebo and 624 +- 53 mumol/l after LTG (NS). Changes in the peak serum concentration, from 9.0 +- 0.3 mumol/l to 9.2 +- 0.4 mumol/l (LTG), and in the time to peak serum concentration, from 9.3 +- 1.1 h to 9.1 +- 1.2 h (LTG), were also not significant. Conclusion: These data support the earlier findings that LTG does not significantly affect the rate or extent of absorption, or elimination of CBZ.