The effect of lamotrigine and carbamazepine on the development of the audiogenic seizure reaction in rats of the Krushinskiĭ-Molodkina strain
Fedotova, I.B.; Semiokhina, A.F.; Kosacheva, E.S.; Bashkatova, V.G.; Raevskiĭ, K.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 59(6): 6-9
1996
ISSN/ISBN: 0869-2092 PMID: 9181879 Document Number: 456322
The effect of Lamotrigine and carbamazepine on the development and character of the epileptiform seizures after strong sonic stimulation were studied on Krushinskiĭ-Molodkina line of rats. Both drugs manifested a dose-dependent increase in the latency of motor reaction Lamotrigine administration in the dose range of 5-40 mg/kg, i.p., resulted in a moderate decrease in the seizure intensity preventing predominantly the tonic component of the seizure and failed to modify the character of convulsive reaction. Carbamazepine administered in doses of 7.5-30 mg/kg effectively prevented the epileptiform seizures. The "two-wave" motor reaction was observed in 15% of carbamazepine-treated rats.