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Increasing threshold of the epileptiform activity in the CA1 field of hippocampal slices of Krushinskiĭ-Molodkina rats as protective adaptation mechanism

Sem'ianov, A.V.; Morenkov, E.D.; Kalemenev, S.V.; Iaroshenko, V.P.; Godukhin, O.V.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 84(5-6): 450-459

1998

ISSN/ISBN: 0869-8139
PMID: 9785410
Document Number: 493764
The Krushinsky-Molodkina rat CA1 hippocampal slices revealed an increased threshold of the epileptiform activity development, a depressed signal transmission in the presynaptic glutamatergic fibres, no long-term increase in excitability of the CA1 pyramidal neurons characteristic of Wistar rats following Mg2+ removal and K+ increase. These events suggest a protective adaptive mechanism preventing propagation of seizure activity into limbic structures of the rats.

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