The effect of carbamazepine on the content of monoamines and their metabolites in the brain structures of rats with audiogenic epilepsy
Kosacheva, E.S.; Kudrin, V.S.; Fedotova, I.B.; Semiokhina, A.F.; Raevskiĭ, K.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 61(3): 25-27
1998
ISSN/ISBN: 0869-2092 PMID: 9690071 Document Number: 486132
It was shown that the content of serotonin (5-OT) and 5-oxyindoleacetic acid (5-OIAA) in the temporal cortex, hippocampus and medulla oblongata and the content of dopamine and 3,4-dihydroxyphenilacetic acid in the striatum are increased initially, while the level of norepinephrine in the striatum is reduced in Krushinskiĭ-Molodkina rats genetically predisposed to audiogenic epilepsy in comparison with Wistar rats. Carbamazepine levelled out the changes in the 5-OT and 5-OIAA levels at the peak of the audiogenic attack in the temporal cortex and hippocampus, causing at the same time a sum increase in the content of all monoamines and their metabolites in the medulla oblongata and striatum.