Pharmacokinetics of muscone in rats, rabbits and dogs
Zhu, Y.W.; Cheng, G.F.; Zhu, X.Y.
Yao Xue Xue Bao 28(3): 177-180
1993
ISSN/ISBN: 0513-4870 PMID: 8368076 Document Number: 414033
The plasma concentration-time course of muscone in rats after a single iv administration fitted well to a two-compartment open model, and those in rabbits and dogs were all conformed to a three- compartment open model. Significant species differences were observed in the pharmacokinetic parameters among rats, rabbits and dogs, while no significant differences were found among the three dosages of 12, 18 and 24 mg/kg after iv administration to rats. In rats, the T-1/2-beta was found to be 118.1 apprx 131.2 min. In rabbits and dogs, the T-1/27b were 24.9 and 30.0 min, respectively and the T-1/2-gamma were 331.9 and 366.4 min, respectively. In rats, rabbits and dogs, the V-ss were 23.0, 51.7 and 7.3 L/kg, respectively, and the V-c were 2.33, 2.13 and 0.38 L/kg, respectively.