Pharmacokinetics of phosphocreatine in the blood serum of man, dogs and rabbits
Afonskaia, N.I.; Shepeleva, I.I.; Aniukhovskiĭ, E.P.; Samarenko, M.B.; Makhotina, L.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 100(11): 591-593
1985
ISSN/ISBN: 0365-9615 PMID: 4063509 Document Number: 265426
It is shown that a single intravenous injection of phosphocreatine to man or to experimental animals is followed by its rapid clearance from blood serum. This clearance is biphasic in nature with a half-life of 3-5 min at the first rapid stage and of 20-33 min at the next slower stage. To maintain the constant phosphocreatine concentration in blood, it is necessary to infuse it at a rate comparable to that of clearance. In particular, in blood serum of man, the phosphocreatine concentration can be kept at the level of 0.2 mM if it is injected at a rate of 60 mg/h per kg bw.