Circadian changes in the pharmacokinetics of triamcinolone acetonide in rabbits
Choi, J.S.; Shin, S.C.; Burm, J.P.
Research Communications in Molecular Pathology and Pharmacology 107(3-4): 233-238
2000
ISSN/ISBN: 1078-0297 PMID: 11484877 Document Number: 516256
Circadian changes in the pharmacokinetics of triamcinolone acetonide were investigated in rabbits after a single intravenous administration of the drug, 1.0 mg/kg, at 08:00 and 20:00. At 20:00 hrs, the area under the plasma concentration-time curve from time zero to time infinity was significantly greater (46% increase), and this could be due to significantly slower total body clearance (31% decrease) than that at 08:00. The terminal half-life was significantly longer (82%) at 20:00. However, the apparent volume of distribution at steady state and total amount of unchanged drug excreted in 12 hr urine were not significantly different between two groups of rabbits.