Pharmacokinetics of phenazone after bilateral ovariectomy in female rabbits
Gawrońska-Szklarz, B.; Kwiatkowski, A.; Droździk, M.; Wójcicki, J.
Ginekologia Polska 63(2): 57-61
1992
ISSN/ISBN: 0017-0011 PMID: 1305588 Document Number: 403484
The aim of this study was to evaluate the influence of female sex hormones on phenazone pharmacokinetics using as an experimental model female rabbits after a bilateral ovariectomy. Eighteen female rabbits divided into two groups: control animals and experimental rabbits, that underwent ovariectomy, were used in the study. Pharmacokinetic assays were performed in all animals: prior to the study, after 1 month and after 2 months. Blood was sampled within 24 hours after intragastric administration of phenazone at a dose 50 mg/kg b.w. Two compartment open model was used for calculations. Significant increase in AUC and prolongation of phenazone halflife as well as a decrease in the total body clearance were noted. The study demonstrated the possible inhibition of the microsomal mixed-function oxidase system by oestrogens.