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A model of the secondary structure and distribution of antigenic determinants in the VP1 protein of hepatitis a virus

Mesianzhinov, V.V.

Biofizika 31(6): 961-963

1986

ISSN/ISBN: 0006-3029
PMID: 2432945
Document Number: 271707
A comparative analysis of amino acid sequence of the proteins VP1 of hepatitis A virus and poliovirus of the 1 type was carried out. A model is proposed of structural organization of VP1 of hepatitis A virus providing the presence of a bilayer core formed by 8 antiparallel beta-strands. Probable candidates for surface antigenic determinants are the amino acid sequences located in unordered fragments of the polypeptide chain (residues 101-106 and 115-125), and alpha-helical region (residues 127-135).

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