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Antigenic determinants of blood serum proteins detected in the structure of hepatitis B surface antigen by the method of affinity chromatography

Burlev, V.A.; Kosik, O.G.; Golosova, T.V.; Vlasikhina, E.M.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 9: 59-65

1977

ISSN/ISBN: 0372-9311
PMID: 74152
Document Number: 123205
Tropism of the antigen of hepatitis B to the antibodies against normal serum proteins was revealed by the method of affine chromatography; this pointed to the possibility of the presence in the HBs-antigen structure of some antigenic determinants of the serum proteins or to the association of serum proteins with the HBs-antigen. A change of the isoelectric spectrum of the HBs-antigen and its tropism in affine chromatography to the antibodies against serum proteins possibly depended both on the nonhomogeneity of the antigenic determinants included into the composition of the antigen, and on the presence of the HBs-antigen--HBs-antibody or HBs-antigen--serum proteins complexes.

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