Lipid peroxidation in the rat liver during macrophage stimulation
Semeniuk, A.V.; Voronin, A.I.; Kulikov, V.I.; Maianskiĭ, D.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(4): 453-455
1986
ISSN/ISBN: 0365-9615 PMID: 3697492 Document Number: 269955
The content of malonyl dialdehyde, one of the final products of lipid peroxidation, was determined at different stages after zymosan stimulation of mononuclear phagocyte system in the rat liver. The gradual increase (with the maximum on day 7) of colloidal carbon clearance from the blood and the number of nonparenchymal cells, especially their nonphagocytic fraction, was noted in the rat liver after zymosan injection. A considerable reduction of hepatic malonyl dialdehyde was observed after the initial (on day 1) rising of its level. The distinct antioxidant effect developed by day 7 and coincided with maximal activity of hepatic macrophages.