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Effect of C27-steroids on lipid peroxidation in rat liver mitochondria

Zozulia, A.L.; Morozova, R.P.; Donchenko, H.V.

Ukrains'kyi Biokhimichnyi Zhurnal 73(2): 79-86

2001

ISSN/ISBN: 0372-3909
PMID: 11642049
Document Number: 532570
The influence of C27-steroids--vitamin D3 and 20-hydroxyecdysone in free-radical reactions on lipid peroxidation in the mitochondrial fraction of rat's liver has been studied. Antioxidant activity of superoxide dismutase and catalase and the content of lipid components--cholesterol and phospholipids has been determined. The assumption was put forward that antioxidant action of steroids was possible as a result of to the modification of mitochondrial membrane through its lipid content and changing of its cholesterol: phospholipids content.

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