Changes in UDP-glucuronosyl-, glutathione-S-transferase and lipid peroxidation in rat liver microsomes during gamma-irradiation and protective effect of alpha-tocopherol
Legon'kova, L.F.; Abakumov, G.Z.; Bushma, M.I.; Lukienko, P.I.
Voprosy Meditsinskoi Khimii 36(3): 26-28
1990
ISSN/ISBN: 0042-8809 PMID: 2116695 Document Number: 349866
Stimulation of lipid peroxidation, accompanied by a decrease in activity of UDP-glucuronyl- and glutathione-S-transferases, was observed in rat liver microsomes within one day after gamma-irradiation. Maximal alteration of the patterns studied was detected within 5 days. Preadministration of alpha-tocopherol, within 14 days at a dose of 200 mg/kg of body mass, prevented distinctly the impairing effect of irradiation.
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