Pre-administration of beta-carotene protects tissue glutathione and lipid peroxidation status following exposure to gamma radiation
Manda, K.; Bhatia, A.L.
Journal of Environmental Biology 24(4): 369-372
2003
ISSN/ISBN: 0254-8704 PMID: 15248648 Document Number: 562879
The present study has been aimed to investigate the protective effect of beta-carotene against radiation-induced oxidative stress in mice tissues using lipid peroxidation and glutathione (GSH) as end points. Fourteen days oral priming administration of beta-carotene (35 mg/kg body weight) followed by an acute dose of gamma radiation (5 Gy) inhibited the augmented level of thiobarbituric acid reactive substance (TBARS) and a statistically significant protection against GSH depletion. Results evaluated from this study clearly indicate the antioxidative property of beta-carotene against gamma radiation, which is suggestive of free radical scavenging and singlet oxygen quenching.