Evaluation of glutathione and ascorbic acid as suppressors of drug-induced lipid peroxidation
Roy, K.; De, A.U.; Sengupta, C.
Indian Journal of Experimental Biology 38(6): 580-586
2000
ISSN/ISBN: 0019-5189 PMID: 11116529 Document Number: 524454
In different sets of experiments, lipid peroxidation induction capacity of two drugs (ceftizoxime sodium, a third generation cephalosporin antibiotic, and acyclovir, an antiviral agent) was studied using goat whole blood as the lipid source. Ceftizoxime sodium caused significant lipid peroxidation. Lipid peroxidation may be related to the toxic potential of the drug. Insignificant induction of lipid peroxidation was found in the case of acyclovir and this is in good agreement with the safety record of the drug. Glutathione and ascorbic acid could significantly reduce ceftizoxime sodium induced lipid peroxidation, suggesting that free radical scavenging action of antioxidants may be exploited by possible antioxidant co-therapy to reduce iatrogenicity of the drug in persons with impaired endogenous antioxidant defence. Glutathione and ascorbic acid appear to be promising candidates for further investigation.