Modulation of glutathione depletion and lipid peroxidation by WR-77913 an 2-mercaptopropionylglycine in cyclophosphamide chemotherapy
Bhanumathi, P.; Devi, P.U.
Indian Journal of Experimental Biology 32(8): 562-564
1994
ISSN/ISBN: 0019-5189 PMID: 7959938 Document Number: 428116
Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MPG or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.