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Lipid peroxidation and the polymerase activities of liver chromatin fractions in rats during aging

Levitskiĭ, E.L.; Gubskiĭ, I.I.; Gol'dshteĭn, N.B.; Litoshenko, A.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 107(6): 693-695

1989

ISSN/ISBN: 0365-9615
PMID: 2790164
Document Number: 328010
Lipids, which enter the composition of actively transcribed and repressed chromatin fractions are found to undergo a peroxidation. This process decreased with aging and more pronounced in actively transcribed chromatin fraction. A decreased activity of DNA polymerase beta and increased activity of RNA polymerase I in this chromatin fraction with aging were observed. It is assumed that observed changes of genome function of old animals may be caused by decreased peroxidation of chromatin lipids.

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