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Calcium transport in endoplasmic reticulum of the rat liver during lipid peroxidation

Gubskiĭ, I.I.; Kurskiĭ, M.D.; Zadorina, O.V.; Fedorov, A.N.; Briuzgina, T.S.; Iurzhenko, N.N.

Biokhimiia 55(1): 12-22

1990

ISSN/ISBN: 0320-9725
PMID: 2140518
Document Number: 349500
Some parameters of calcium transport in rat liver microsomes under conditions of lipoperoxidation activation modelled by antioxidant deficiency (AOD) were studied. This process was shown to be associated with a sharp stimulation of NADPH- and ascorbate-dependent lipid peroxidation in hepatocyte endoplasmic reticulum. The activation of lipid peroxidation was accompanied by disturbances in the kinetic properties of Ca2(+)-ATPase. This was paralleled with a considerable decrease of the ATP-dependent 45Ca-accumulation, increase in the passive permeability of microsomal vesicles for Ca2+ and Ca2+ elevation in the microsomal fraction. The AOD-induced diminution of the Ca2(+)-pump efficiency was slightly prevented by injections of rats with the antioxidants, alpha-tocopherol acetate and ionol which enable Ca2+ compartmentation correction in liver cytosol and membrane fractions.

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