Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: I. The role of peroxidation of membrane phospholipids
Kagan, V.E.; Savov, V.M.; Serbinova, E.A.
Acta Physiologica et Pharmacologica Bulgarica 10(2): 73-81
1984
ISSN/ISBN: 0323-9950 PMID: 6485825 Document Number: 238541
It was demosntrated that endogenous lipid peroxidation (LPO) is an effective mechanism of disassembly of endoplasmic reticulum membranes and cytochrome P-450 (P-448) in the liver. The rate of cytochrome P-450 (P-448) degradation in vivo can be regulated by free radical scavengers. The constitutive forms of cytochrome P-450 (P-448) are less sensitive to LPO induced in vivo or in vitro than the inducible ones.