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Study of the mechanism of initiation of enzymatic NADPH-dependent lipid peroxidation in membranes of the endoplasmic reticulum

Kagan, V.E.; Serbinova, E.A.; Minin, A.A.; Savov, V.M.; Novikov, K.N.

Biokhimiia 50(6): 986-991

1985

ISSN/ISBN: 0320-9725
PMID: 2992614
Document Number: 247151
The localization and mechanism of generation of active oxygen species in the enzymatic NADPH-dependent lipid peroxidation system in liver microsomes were studied. Using the spin-trapping method, the key role of active oxygen species in the initiation of NADPH-dependent enzymatic lipid peroxidation was confirmed. It was shown that active oxygen species are generated via consecutive one-electron reduction of the oxygen molecule by NADPH-cytochrome P-450 reductase.

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