NADPH- and NADH-dependent benz (a) pyrene hydroxylating system. II. Relationship to lipid peroxidation
Belevich, N.P.; Dmitriev, L.F.; Ivanov, I.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 91(2): 158-160
1981
ISSN/ISBN: 0365-9615 PMID: 7225548 Document Number: 181798
It has been shown with reference to liver microsomes prepared in the presence and in the absence of alpha-tocopherol that structural alterations that may arise from the isolation procedure may affect interplay of carriers in NADP.H oxidation. Study of these alterations is of importance for understanding the influence of different factors of NADP.H oxidase on the involvement of NAD.H in benz(a)pyrene hydroxylation. If the electron transport via NADP.H-dependent flavoprotein is limited, the intense hydroxylation of benz(a)pyrene can be supported by means of chains involved in NAD.H oxidation. Studies have been focused on utilization of NAD.H in benz(a)pyrene hydroxylation and lipid peroxidation.