Effect of benznidazole on the mixed function oxygenase system from rat liver microsomes
Masana, M.; de Toranzo, E.G.; Rubio, M.; Castro, J.A.
Archives Internationales de Pharmacodynamie et de Therapie 276(1): 4-11
1985
ISSN/ISBN: 0003-9780 PMID: 4051638 Document Number: 246583
Previous benznidazole (Bz) administration to rats (30 mg/kg, i.p.) significantly prolonged their pentobarbital sleeping time. This prolonging effect of Bz administraztion correlates with the inhibitory action of Bz on the liver aminopyrine or ethymorphine N-demethylase activities. Inhibition of these enzyme systems by Bz is non-competitive and would not be related to changes in liver microsomal cytochrome P-450 (P-450) content or in cytochrome c-reductase activity or to interactions of Bz with P-450 leading to spectral changes. Covalent interactions of Bz reactive metabolites with microsomal proteins or phospholipids might be involved instead.