Metabolism of hepatic lipids in alloxan diabetes
Chauhan, U.P.; Jaggi, C.B.; Ahuja, H.C.; Singh, V.N.
Indian Journal of Experimental Biology 22(7): 386-390
1984
ISSN/ISBN: 0019-5189 PMID: 6510970 Document Number: 222644
Alloxan diabetes in rats caused 5-fold increase in the level of hepatic triglyceride. The levels of monoglyceride, phosphatides and cholesterol were marginally increased. In vivo incorporation of (U-14C)glucose and (1-14C) palmitic acid into hepatic lipids of normal control, diabetic and insulin-treated diabetic rats revealed preferential utilization of Sn glycerol-3-phosphate and fatty acids for the synthesis of triglyceride rather than for phosphatides. Quantitation of individual phosphatides indicated that the increase was restricted to lysophosphatidylcholine, phosphatidylcholine and phosphatidylethanolamine. In vivo incorporation of 32Pi into phosphatidylcholine and lysophosphatidylcholine was increased suggesting increased turnover of hepatic phosphatidylcholine in diabetes. Insulin treatment to diabetic rats restored lipid metabolism almost to normal. [Implications with respect to the development of fatty liver are presented.].