Protection against alloxan-induced diabetes by various dialkyldithiocarbamates
Masukawa, T.; Nakanishi, K.; Katakawa, J.; Tetsumi, T.
Experientia 51(1): 29-31
1995
ISSN/ISBN: 0014-4754 PMID: 7843327 Document Number: 454498
Dialkyldithiocarbamates injected into mice 0.5 h prior to alloxan protected dose-dependently against the diabetogenic action of alloxan, and increased blood glucose levels at the time of alloxan injection. Furthermore, they exhibited anti-oxidative properties in vitro such as inhibition of lipid peroxidation, removal of hydrogen peroxide and reduction of the stable free radical, 1, 1-diphenyl-2-picrylhydrazyl (DPPH). These results suggest that dialkyldithiocarbamates protect against the development of alloxan-induced diabetes by the indirect mechanism of producing hyperglycemia at the time of alloxan injection and possibly by their anti-oxidative effects as well.