Lymphopoietic function of mice with alloxan diabetes
Kozlov, I.A.; Timofeeva, E.E.; Zinger, M.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(4): 407-409
1986
ISSN/ISBN: 0365-9615 PMID: 3697485 Document Number: 281641
Alloxan diabetes (sucrose blood concentration greater than or equal to 14 mmol/l) induced lymphocytopenia in noninbred male mice, resulting from the decrease in the number of both T and B lymphocytes differentiated by their reaction to acid phosphatase. At the same time thymic bone marrow lymphopoiesis in mice with diabetes was depressed. Nodular and splenic lymphopoiesis remained virtually unchanged. These disturbances became apparent on the 3rd week after diabetes induction. Alloxan itself has no inhibitory effect on lymphopoiesis.