Free radical processes in the pathogenesis of alloxan diabetes
Bobyrev, V.N.; Pocherniaeva, V.F.; Dumenko, I.L.; Bobyreva, L.N.
Problemy Endokrinologii 38(6): 55-57
1992
ISSN/ISBN: 0375-9660 PMID: 1302853 Document Number: 395384
Presents the results of studies of carbohydrate and peroxide metabolism, of antioxidant content in rats with alloxan diabetes under various levels of alimentary antioxidant consumption. Alloxan administration was found to result in biochemical and morphologic shifts characteristic of diabetes mellitus. The development of these changes runs against the background of enhanced free-radical processes. Simulation of alloxan diabetes in deficiency of alimentary antioxidants is conducive to the development of alloxan diabetes. The authors discuss the contribution of free-radical processes to the pathogenesis of alloxan diabetes and come to a conclusion on the usefulness of including antioxidant drugs in to a complex of therapeutic measures in this condition.