State of free radical processes, metabolism of nitrogen oxide, iron and cortisol level in autohemotransfusion and transfusion of the donor blood
Lazarev, S.M.; Korableva, N.P.
Vestnik Khirurgii Imeni I. I. Grekova 165(5): 72-75
2006
ISSN/ISBN: 0042-4625 PMID: 17315693 Document Number: 605040
Under study were the main regularities of changes in processes of peroxidation and antioxidant defense in patients with different methods of operative hemorrhage replacement. Autohemotransfusion was fulfilled in 33 patients; donor blood was transfused to 33 patients. It was concluded that donor blood transfusion gave rise to activation of lipid peroxidation processes and decrease of antiradical activity. Elevation of the level of nitrogen oxide in the group of patients with transfused donor blood was due to its participation in the mechanisms of antioxidant defense. The content of serum iron was reliably higher on the 10th day of the postoperative period in the group of patients with transfused donor blood. The content of ferritin in the group of patients with transfused donor blood was lower before anesthesia and by the moment of blood replacement. High indices of cortisol in patients with transfused donor blood within 4-6 hours after operation suggest that it has a more pronounced stress-realizing effect than autohemotransfusion.