Dynamics of free-radical oxidation processes in transplantable sarcoma-45 as indicator of tumor and body interaction
Sharipov, F.K.; Balenkov, I.O.; Kireev, G.V.
Voprosy Onkologii 51(2): 227-229
2005
ISSN/ISBN: 0507-3758 PMID: 16223007 Document Number: 588961
Induced chemoluminescence was used for 30 days to measure lipids peroxidation in transplantable sarcoma-45 homogenates in 83 noninbred male rats. It was found that tumor/body interaction can be interpreted in terms of free-radical oxidation processes taking place in tumor tissue. In the middle of the experiment, the kinetics of chemoluminescence soared up which was accompanied by slight increase in tumor mass. Later on, tumor growth involved a rise in antioxidant enzyme levels which is supposedly accounted for by the expression of the genes responsible for the rate of antioxidant reactions in general. That increase resulted in uncontrollable growth of tumor.