The effect of short-term alloxan-induced diabetes on the activity of drug metabolizing enzymes
Pachecka, J.; Kobylińska, K.; Suchocka, Z.; Kuczyńska, J.
Acta Poloniae Pharmaceutica 50(6): 435-439
1993
ISSN/ISBN: 0001-6837 PMID: 8067257 Document Number: 419168
Chemical diabetes produced in male rats by treatment with alloxan (45 mg/kg) decreased aminopyrine N-demethylase activity but not hepatic microsomal protein, cytochrome P-450 and cytochrome b5 contents. In contrast, diabetes increased aniline hydroxylase activity. Glutathione S-transferase activity and the most of the forms of UDP-glucuronyltransferase were decreased but phenolsulphotransferase activity was not affected in alloxan-induced rats. These results suggest that observed changes may led to alteration of drug metabolism and toxicity in diabetes.