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Effect of alloxan induced mild insulin dependent diabetes mellitus on rat erythrocyte cytosolic dehydrogenases

Gupta, D.K.; Ahmad, F.; Suhail, M.

Indian Journal of Experimental Biology 34(3): 262-263

1996

ISSN/ISBN: 0019-5189
PMID: 8781036
Document Number: 456858
In order to understand how the red cell of mild insulin dependent diabetes. mellitus rat perform the normal physiological function and maintain integrity cytosolic dehydrogenases were assayed. Lactate dehydrogenase produces the cofactor for glycolytic enzymes while glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase produces the coenzymes for oxygen radical scavenging enzymes. Decrease in activity of cytosolic dehydrogenase renders diabetic erythrocyte population more susceptible to oxidant stress.

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