New techniques in the pharmacokinetic analysis of cancer drugs. I. Mass spectrometry: recent technical developments and applications in cancer chemotherapy
Gouyette, A.
Cancer Surveys 17: 397-405
1993
ISSN/ISBN: 0261-2429 PMID: 8137349 Document Number: 419169
Mass spectrometry has emerged as a powerful tool for studying the fate of drugs in living organisms, especially when used in conjunction with new techniques of ionization, such as fast atom bombardment or the ion spray technique, and efficient detectors. New ionization techniques have led to the development of high performance liquid chromatography-mass spectrometry interfaces that combine the separation efficiency of HPLC and the power of mass spectrometry for determination of the molecular weight of complex macromolecules and identification of the structure of drugs and their biotransformation products.