Influence of anxiogenic stress upon severity of alloxan-induced pancreatic and hepatic damage
Volchegorskiĭ, I.A.; Tseĭtlikman, V.E.; Tseĭtlikman, O.B.; Ship, S.A.; Bubnov, N.V.; Sinitskiĭ, A.I.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2005(8): 21-25
2005
ISSN/ISBN: 0869-6047 PMID: 16149431 Document Number: 591833
4 episodes of immobilization stress caused anxious and depressive behavioral disorder in rats, accompanied by decreased sensitivity of pancreatic tissue to alloxan-induced damage, and simultaneously increased sensitivity of hepatic tissue to alloxanogenic inflammatory effect. The latter shifts were accompanied by a more pronounced hyperglycemia. The paper discusses a probable role of hepatitis in hyperglycemic response to alloxan challenge associated with stressogenic anxiety.