Metabolism of riboflavin and its nucleotides in rat liver subcellular fractions in alloxan diabetes
Kuznetsova, L.N.; Shestopalova, V.M.
Voprosy Pitaniia 1: 21-24
1975
ISSN/ISBN: 0042-8833 PMID: 1210179 Document Number: 88153
In alloxan-induced diabetes the content of riboflavin and FMN goes up in all of the subcellular fractions and that of FAD in the nuclear liver fraction alone. While administration of insulin to control animals reduces the riboflavin and FMN level in all of the subcellular fractions of the liver, in the diabetic animals such a decline is observed in the nuclei alone. Insulin brings down the FAD level in the nuclear liver fraction of both the control and test animals. An additional introduction of riboflavin depresses and that of FMN - raises the FAD content in diabetic animals as compared to controls.