Role of age in the interaction of tetracycline with the subcellular fractions of rat liver homogenate
Guliaev, A.E.; Kivman, G.I.; Nadirova, B.A.
Antibiotiki 27(10): 776-778
1982
ISSN/ISBN: 0003-5637 PMID: 7149684 Document Number: 192595
The effect of the rat age on the binding of tetracyclines to the subcellular fractions of liver homogenates was studied. The tetracyclines significantly lost their activity after the contact with the cell organoids. The level of the binding was lower in the newborn and old rats, the complex of tetracycline with mitochondria being less stable. The greater part of the antibiotic reduced its activity after washing of the organoids. The deposition of the antibiotics in the cells was the most pronounced in the pubertal animals.