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Effects of cicloxilic acid on liver subcellular fractions triglyceride content in acute ethanol intoxication

Averame, M.M.; Pronzato, M.A.; Cottalasso, D.; Gambella, G.R.; Marinari, U.M.; Nanni, G.

Arzneimittel-Forschung 28(7a): 1221-1223

1978

ISSN/ISBN: 0004-4172
PMID: 582959
Document Number: 131928
The action of cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) on the concentration of triglycerides in the subcellular compartments of the liver was investigated in acutely ethanol-intoxicated rats. Cicloxilic acid is able to significantly reduce the accumulation of neutral fats in the homogenate and in the cytosol and to shorten the steatosis regression time. The triglyceride content in total microsomes results slightly higher in the animals treated with cicloxilic acid than in those treated with ethanol only. The data are discussed in relation to the pathogenesis of ethanol fatty liver and to the possible mechanism of action of cicloxilic acid.

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