Liver triglyceride accumulation after chronic ethanol administration: a possible protective role of metadoxina and ubiquinone
Marchi, S.; Polloni, A.; Costa, F.; Bellini, M.; Bonifazi, V.; Tumino, E.; Grassi, B.; Romano, M.R.; De Bartolo, G.; Bertelli, A.
International Journal of Tissue Reactions 12(4): 247-250
1990
ISSN/ISBN: 0250-0868 PMID: 2283204 Document Number: 364127
Hepatoprotective actions of metadoxina and ubiquinone have been studied in alcoholic rats by evaluating hepatic triglyceride accumulation and serum biochemical parameters of liver function. The two drug-treated groups displayed significantly lower triglyceride concentrations as compared to the ethanol-treated group. No significant differences were found among the two drug-treated and the control groups. Electron-microscopic abnormalities were found only in ethanol-treated rats. Serum biochemical parameters of liver function did not show any significant difference among all four groups. These results suggest a possible protective role of metadoxina and ubiquinone in ethanol-induced liver triglyceride accumulation.