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Naphthofuran derivatives with potential beta-adrenolytic activity

Garuti, L.; Ferranti, A.; Giovanninetti, G.; Gaggi, R.

Il Farmaco; Edizione Scientifica 38(7): 527-532

1983

ISSN/ISBN: 0430-0920
PMID: 6137412
Document Number: 218171
1-(Naphtho[1,2-b]furan-2-yl)-2-(isopropylamino)ethanol (II) and 1-(naphtho[2,3-b]furan-2-yl)-2-(isopropylamino)ethanol (III) show low beta-adrenergic blocking activity and unlike the naphtho [2,1-b]furan derivatives (1,2) do not appear to give rise to metabolites with high beta-adrenoceptor inhibitory properties. The inclusion of the --OCH2-- moiety in an aromatic nucleus larger than the benzofuran system (bufuralol, Ro 3-3528) caused loss of the biological activity.

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Linée, P.; Le Pollès, J.B.; Lacroix, P.; Pape, D.; Quiniou, P.; Van den Driessche, J. 1977: Effects of a beta-adrenolytic and a diuretic vis-à-vis hyper-reninemia induced by isoprenaline in anesthetized dogs. Value of beta blocking-diuretic interaction Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 171(1): 218-223
Martani, A.; Fravolini, A.; Schiaffella, F.; Orzalesi, G.; Selleri, R.; Volpato, I. 1975: Pyridine derivatives with potential antiviral activity Bollettino Chimico Farmaceutico 114(10): 590-597
Burak, K.; Machoń, Z. 1992: Synthesis of isothiazole derivatives with potential biological activity Die Pharmazie 47(7): 492-495
Wyrzykiewicz, E.; Lapucha, A.; Golankiewicz, K.; Kucharski, S.; Krysiński, J. 1981: New N-substituted derivatives of E-2'- and E-3'- hydroxystilbazoles-(4) of potential antimicrobial activity Die Pharmazie 36(6): 407-410
Witkiewicz, K.; Rykowski, Z.; Machoń, Z.; Lipnicka, U.; Burak, K. 1988: Synthesis of p-menthane derivatives with potential biological activity Die Pharmazie 43(2): 84-86
Bartoń, H. 1979: Synthesis of new benzophenone derivatives with potential antiinflammatory activity Polish Journal of Pharmacology and Pharmacy 31(2): 169-174
Strzelczyk, M. 1984: Synthesis of perhydro-1,2,5-dithiazepine derivatives of potential pharmacological activity Polish Journal of Pharmacology and Pharmacy 36(5): 473-484
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Pecorari, P.; Vampa, G.; Rinaldi, M. 1987: Compounds with potential anticancer activity. Benzenesulfonamido-pyrimidine derivatives Il Farmaco; Edizione Scientifica 42(7): 499-503
De Vita, C.; Cadel, A.; Carú, B.; Mazzini, C.; Parenti, G.F. 1973: Use of beta-adrenolytic agent in the treatment of angina pectoris Minerva Cardioangiologica 21(4): 304-316
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