Pharmacologic evaluation of p-hydroxyacetophenone derivatives as potential beta-adrenolytics
Racanská, E.; Kozlovský, J.
Ceska a Slovenska Farmacie Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti 43(4): 169-170
1994
ISSN/ISBN: 1210-7816 PMID: 7915177 Document Number: 437906
The anti-isoprenaline and negative inotropic activity in the electrically stimulated guinea-pig left atria as well as the local anaesthetic activity of three 4-(2-hydroxy-3-isopropyl-aminopropoxy)-3-(alkoxymethyl) acetophenone derivatives were evaluated. The efficiency of the compounds was compared with the beta-adrenolytic drug atenolol. All of the compounds tested exhibited a statistically significant anti-isoprenaline activity, which increased from the propoxy- to heptyloxyderivative. However, the nonspecific cardiodepressive and local anaesthetic effects of the drugs increased in the same order: propoxy- < pentyloxy- < heptyloxyderivative.