Histologic evaluation of potential new beta-adrenolytics
Cizmáriková, R.; Pazin, E.; Hricková
Ceskoslovenska Farmacie 41(7-8): 264-265
1992
ISSN/ISBN: 0009-0530 PMID: 1362693 Document Number: 404736
The present paper investigated histological changes in the myocardium in two potential beta-adrenolytic agents, 4-acetophenon e after intravenous administration in doses of 8 mg/kg and 24 mg/kg. It results from the found data that in both agents in the doses used there are no necrotic changes in the myocardium and the values of the impairment range within the 1st degree of Zbinden's classification, comparable to the standard metipranolol.
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