Compounds with potential anticancer activity. Benzenesulfonamido-pyrimidine derivatives
Pecorari, P.; Vampa, G.; Rinaldi, M.
Il Farmaco; Edizione Scientifica 42(7): 499-503
1987
ISSN/ISBN: 0430-0920 PMID: 3666123 Document Number: 289236
Some derivatives of N-(5-pyrimidinyl)benzenesulfonamide, variously substituted at the benzene and pyrimidine ring, and variously methylated at ring and/or sulfonamidic nitrogens, were re-prepared. The activity of these compounds against lymphocytic leukemia P388 was evaluated and proved to be negligible or completely absent.
Document emailed within 1 workday
Related Documents
Picciòla, G.; Ravenna, F.; Carenini, G.; Manzardo, S.; Gentili, P. 1981: Heterocyclic compounds containing a 4-aminophenylalkanoic acid group with potential antiinflammatory activity. II. 2-Substituted morpholine derivatives Il Farmaco; Edizione Scientifica 36(1): 47-60Cavalleri, B.; Bellasio, E. 1970: Fluorinated organic compounds with potential biological activity. 8. Synthesis of beta-fluoro-beta-arylethylamine-N-derivatives Il Farmaco; Edizione Scientifica 25(12): 901-911
Ali, K.A.; Ragab, E.A.; Farghaly, T.A.; Abdalla, M.M. 2011: Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents Acta Poloniae Pharmaceutica 68(2): 237-247
Pluta, J.; Flendrich, M.; Cieplik, J. 1996: Synthesis and biological activity of some pyrimidine derivatives Bollettino Chimico Farmaceutico 135(8): 459-464
Krepelka, J.; Kotva, R.; Vachek, J.; Holubek, J.; Mĕlka, M.; Maturová, E.; Grimová, J. 1986: Synthesis and pharmacologic activity of pyrimidine derivatives Ceskoslovenska Farmacie 35(10): 433-439
Prakash, L.; Shaihla; Malik, S.; Mital, R.L. 1989: Synthesis and antibacterial activity of some new pyrido[2,3-d]pyrimidine derivatives Die Pharmazie 44(7): 490
Sayed, H.H.; Shamroukh, A.H.; Rashad, A.E. 2006: Synthesis and biological evaluation of some pyrimidine, pyrimido[2,1-b][1,3]thiazine and thiazolo[3,2-a]pyrimidine derivatives Acta Pharmaceutica 56(2): 231-244
Wolski, T. 1978: The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds. I. Synthesis of azathioprine Polish Journal of Pharmacology and Pharmacy 30(4): 593-599
Slabnov, I.D.; Cherepnev, G.V.; Tsibul'kin, A.P.; Karimova, F.G.; Garaev, R.S. 1998: The effect of pyrimidine derivatives on the sulfhydryl status of immunocompetent cells in vivo: the interrelationship with Ca2(+)-ATPase and antimutagenic activity Eksperimental'naia i Klinicheskaia Farmakologiia 61(1): 40-43
Kadłubowski, R.; Strzelczyk, M. 1985: Study of compounds with potential antiparasitic action. VII. Ether derivatives of perhydro-1,4-thiazepine Wiadomosci Parazytologiczne 31(2): 163-168
Kadłubowski, R. 1978: Study of compounds with potential antiparasitic action. II. new homomorpholine derivatives containing ether bonds Wiadomosci Parazytologiczne 24(5): 581-584
Castillo-González, D.; Pérez-Machado, G.; Pallardó, F.; Garrigues-Pelufo, T-María.; Cabrera-Pérez, M-Angel. 2012: Computational tools in the discovery of new G-quadruplex ligands with potential anticancer activity Current Topics in Medicinal Chemistry 12(24): 2843-2856
Grasso, S.; Chimirri, A.; Monforte, P.; Fenech, G.; Zappalà, M. 1986: Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine Il Farmaco; Edizione Scientifica 41(9): 713-721
Passarotti, C.M.; Valenti, M.; Marini, M. 1995: In the search for new antiinflammatory drugs: synthesis and antiinflammatory activity of some Thiazolo(3,2-a)pyrimidine derivatives containing a thioether group Bollettino Chimico Farmaceutico 134(11): 639-643
Bellini, A.; Quaglio, M.P.; Guarneri, M.; Cavazzini, G. 1986: Antibacterial activity of cholane compounds: amido and amino derivatives (VI) Bollettino Chimico Farmaceutico 125(9): 362-365
Maczyński, M.; Zimecki, M.ł; Ryng, S.ła. 2008: A new class of isoxazole derivatives: the M 1-9 series of compounds with immunotropic activity Acta Poloniae Pharmaceutica 65(2): 241-244
Ficarra, P.; Ficarra, R.; Tommasini, A.; Fenech, G. 1983: Compounds with potential antitumor activity. II. N,N'-(1-Diadamantandicarboxyamides) Il Farmaco; Edizione Scientifica 38(6): 418-424
Abignente, E.; Arena, F.; De Caprariis, P.; Nuzzetti, R.; Marmo, E.; Lampa, E.; Rosatti, E.; Ottavo, R. 1981: Research on heterocyclic compounds. X.-Imidazo[1,2-a]pyrazine derivatives: synthesis and antiinflammatory activity Il Farmaco; Edizione Scientifica 36(1): 61-80
Shchaveleva, I.L.; Kochetkova, S.V.; Tsilevich, T.L.; Vladyko, G.V.; Korobchenko, L.V.; Boreko, E.I.; Smirnov, I.P.; Khorlin, A.A.; Gottikh, B.P.; Florent'ev, V.L. 1989: Compounds, similar to acyclovir V. Synthesis and antiviral activity of carbethoxyalkoxymethyl derivatives of nucleic bases Bioorganicheskaia Khimiia 15(7): 960-968
Mazza, M.; Pagani, G.; Calderara, G.; Vicarini, L. 1974: Phytotoxic activity of triazene derivatives. II. 1-phenyl-3,3-dialkyltriazene variably monosubstituted benzene compounds Il Farmaco; Edizione Scientifica 29(1): 58-72