A new class of isoxazole derivatives: the M 1-9 series of compounds with immunotropic activity
Maczyński, M.; Zimecki, M.ł; Ryng, S.ła.
Acta Poloniae Pharmaceutica 65(2): 241-244
2008
ISSN/ISBN: 0001-6837 PMID: 18666432 Document Number: 616198
The isoxazole derivatives are interesting objects for synthesis in the search for various sorts of biological activity. Looking for more active immunomodulators we synthesized a series of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides in the reaction of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide with isocyanates and isothiocyanates. The biological effect of these compounds on the proliferative response of human mononuclear peripheral blood cells to phytohemagglutinin A (PHA) was described.
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