The effect of pyrimidine derivatives on the sulfhydryl status of immunocompetent cells in vivo: the interrelationship with Ca2 (+) -ATPase and antimutagenic activity
Slabnov, I.D.; Cherepnev, G.V.; Tsibul'kin, A.P.; Karimova, F.G.; Garaev, R.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 61(1): 40-43
1998
ISSN/ISBN: 0869-2092 PMID: 9575411 Document Number: 488504
It was demonstrated in experiments on guinea pigs that a 30 mg/kg dose of ximedon changes the content of SH-groups in immunocompetent cells depending on the duration of drug administration and the organ to which the cells under test belong. Maximum increase of the SH-groups was recorded in the thymocytes. The dynamics of changes in Ca(2+)-ATPase activity repeated the fluctuations in the SH-group content in the splenic and bone marrow cells. In the bone marrow cells of CBA x C57B1 mice 3 mg/kg ximedon suppressed the induction of chromosome aberrations caused by cyclophosphane. The interrelationship of changes in the cell sulfhydryl status with Ca(2+)-ATPase activity and the antimutagenic effect of ximedon is discussed.