Effect of hydroxylated pyrimidine derivatives on activities of thiamine-dependent enzymes and some parameters of lipid metabolism in mice
Oparin, D.A.; Gorenshteĭn, B.I.; Karaedova, L.M.; Naruta, E.E.; Zabrodskaia, S.V.; Rudiak, T.V.; Akat'ev, V.E.; Larin, F.S.
Ukrainskii Biokhimicheskii Zhurnal 69(1): 37-41
1997
ISSN/ISBN: 0201-8470 PMID: 9454376 Document Number: 473033
It has been found that hydroxylated pyrimidine derivatives actively participate in metabolic processes related to functioning of vitamin B1-dependent enzymes (transketolase, 2-oxo acid dehydrogenase). Hydroxypyrimidines also induce a significant increase in the levels of total lipids and cholesterol in the mice liver, not changing the phospholipid content.
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