The effect of bemitil on the parameters of lipid peroxidation and nitrogen metabolism in epilepsy in children

Mikhałlov, I.B.; Guzeva, V.I.; Sharf, M.Ia.; Basharina, O.B.; Chałka, N.A.

Eksperimental'naia i Klinicheskaia Farmakologiia 60(3): 20-22

1997


ISSN/ISBN: 0869-2092
PMID: 9324390
Document Number: 1254
Epileptic patients given phenobarbital (3 mg/kg. n = 8) or finlepsin (20 mg/kg, n = 7) were found to have a statistically significant increase (p lt 0.05) in the parameters of the lipid peroxidation end product malonic dialdehyde in the erythrocytes (3.34 + 1.13 mu-mol/liter) and blood plasma (0.099 +- 0.04 mu-mol/ liter) in comparison to the control group (n = 9; 1.58 +- 0.96 mu-mol /liter and 0.045 +- 0.02 mu-mol/liter, respectively). The urea level (6.7 +- 1.28 mu-mol/liter) and the ammonia level (31.59 +- 10.46 mu-mol /liter) increase were statistically insignificant as compared to the controls (5.76 +- 0.66 mu-mol/liter and 26.41 +- 5.96 mu-mol/ liter, respectively). Bemytil (n = - 7) in a dose of 20 mg/kg reduced in 10 days the amount of malonic dialdehyde in the erythrocytes (1.57 +- 0.61 mu-mol/liter, p lt 0.05) and plasma (0.043 +- 0.02 mu-mol/liter, p lt 0.05) as well as the amount of urea (3.76 +- 0.96 mu-mol/liter, ) and ammonia p lt 0.05) and ammonia (18.17 +- 2.02 mu-mol/liter, p lt 0.05) in the blood. A favorable therapeutic effect (lesser frequency of seizures and lesser asthenia of the of the children) was observed at the same time. The frequency of paroxysms reduced to 50% in 4 patients (2 with complex-partial seizures, one with absence, and one with simple-partial seizures) and to 75-% in the fifth patient with complex-partial seizures. The therapeutic effect in the 6th and 7th patients could not be evaluated.

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The effect of bemitil on the parameters of lipid peroxidation and nitrogen metabolism in epilepsy in children