Inheritance of high leukocyte folate binding activity. Relationship between folate binding in leukocytes and serum
Holm, J.; Hansen, S.I.; Lyngbye, J.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 53(4): 383-385
1983
ISSN/ISBN: 0300-9831 PMID: 6668138 Document Number: 217246
Folate binding was determined in leukocyte lysates from relatives of three persons whose leukocytes contained large amounts of folate binding protein. A pedigree analysis showed that high leukocyte folate binding activities occurred with great frequency in these families suggesting a dominant mode of inheritance. Folate binding in serum varied within narrow limits (0.2-0.5 nmol folate/l serum) in persons with leukocyte folate binding activities less than 0.8-1.0 nmol folate per 10(9) cells. A shift to a higher level of serum folate binding (greater than or equal to 1.0 nmol/l serum) was, however, observed at leukocyte folate binding activities above that value.