The effect of folate binding protein on the colony-forming activity of GM-CFC cells in vitro
Pristoupilová, K.; Hermanová, E.; Slavíková, V.; Holý, P.
Folia Haematologica 113(6): 759-765
1986
ISSN/ISBN: 0323-4347 PMID: 2436988 Document Number: 281994
A modified method for the preparation of specific folate binding protein was described. The GM-CFC stimulating activity of this SFBP preparation was investigated on tissue cultures of human bone marrow cells. It has been found that in the presence of HPCM the cell proliferation was markedly increased by the SFBP. In the absence of HPCM, however, the cell proliferation has been influenced either positively or negatively presumably in dependence on the expression of folate receptors on the GM-CFC bone marrow cells.