The effect of autoblood in a hyposmotic state on the colony-forming activity of hematopoietic stem cells
Mal'tseva, V.V.; Sergienko, V.I.
Biokhimiia 57(9): 1383-1388
1992
ISSN/ISBN: 0320-9725 PMID: 1467358 Document Number: 389276
It has been shown that hypoosmotic autoblood injected sub- or intracutaneously stimulates the colony-forming activity of haemopoietic stem cells in mice. Autoblood injected to animals immediately after their irradiation stimulates haemopoiesis even after a single dose. When mice are injected with autoblood prior to irradiation, the time between the first injection and the day of irradiation is critical for manifestation of the immunomodulating effect. Autoblood infusions immediately before, the day before, or two days before irradiation markedly deteriorate the clinical status of experimental animals and cause death in some of them. It is suggested that stimulation of haemopoiesis is associated with the appearance in the blood stream of a population of radiosensitive cells, apparently T-cell precursors.