Quantitative and qualitative effects of N10-methylfolate on high-affinity folate binding in human leukocytes
Holm, J.; Hansen, S.I.; Lyngbye, J.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 54(2-3): 195-197
1984
ISSN/ISBN: 0300-9831 PMID: 6500843 Document Number: 230190
N10-methylfolate acted as a potent competitive inhibitor of high-affinity [3H] folate binding in human leukocytes, while methotrexate had no effect. Furthermore, folate binding changed into a non-cooperative type in the presence of N10-methylfolate. Hence, in qualitative and quantitative respects, the substrate specificity characteristics of leukocyte folate binding resemble those of other high-affinity folate binding systems.
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