Role of folate binding proteins in folate metabolism
Kane, M.A.; Waxman, S.
Laboratory Investigation; a Journal of Technical Methods and Pathology 60(6): 737-746
1989
ISSN/ISBN: 0023-6837 PMID: 2659886 Document Number: 3550
The essential role of folates in cellular biochemistry is well established, but the nature of the participation by folate-binding proteins has been disputed. This review will define folate-binding proteins and distinguish them from low-affinity, nonspecific folate binders and folate-dependent intracellular enzymes. We outline changes in plasma folate-binding proteins in various clinical states, review their postulated functions, detail the biochemistry of mammalian soluble folate-binding proteins and their membrane-bound immunologically cross-reactive possible precursors, and present evidence that the latter proteins may function as the physiologic folate receptors and intracellular regulators of folate coenzyme availability.
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